Kafeina, gjenotipet e cyp1a2 dhe rreziku i infarktit të miokardit
DOI:
https://doi.org/10.55312/op.vi2.4369Abstract
Infarkti i Miokardit është një nga patologjitë me rrezik për jetën. Qëllimi i këtij studimi është njohja e lidhjes mes konsumit të kafes me sëmundjet kardiovaskulare. Metodat: Studimi është realizuar duke grumbulluar informacione nga farmacitë e rrjetit të hapur në Tiranë, në Q.S.U.T. “Nënë Tereza” dhe në Durrës. Për çdo pacient u morën të dhëna mbi moshën, profesionin, përdorimin e kafesë, duhanit, pijeve energjike, aktivitetin fi zik dhe historinë familjare. Të dhënat janë përpunuar në mënyrë statistikore. Janë marrë edhe mostra - rast – kontroll për të përcaktuar në mënyrë eksperimentale lidhjen mes konsumit të kafesë, gjenotipeve të CYP1A2 me rrezikun për IM.Keywords:
Gjenotip, CYP1A2, 1F, infarkt miokardi, metabolizëmDownloads
References
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Cammack, R., Oxford Dictionary of Biochemistry and Molecular Biology - Revised Edition. Oxford University Press; 2006; 493–498.
-
Kot, M. & Daniel, W.A., Caff eine as a marker substrate for testing cytochrome P450 activityin human and rat.Pharmacol Rep.2008; 60(6):789-797.
-
R. Viani, “The composition of coff ee”, in Caff eine, Coff ee and Health, S. Garatini, Ed. Raven Press, New York, NY, USA ; 1993; 17–41.
-
L. Missiaen, J. B. Parys, H. De Smedt, B. Himpens, and R. Casteels,“Inhibition of inositol trisphosphate-induced calcium release
-
by caff eine is prevented by ATP”, Biochemical Journal, 1994; 300:1; 81–84.
-
C. Martin, C. Dacquet, C. Mironneau, and J. Mirroneau, “Caff eine-induced inhibition of calcium channel current in cultured smooth muscle cells from pregnant rat myometrium”, British Journal of Pharmacology, 1989; 98; 2; 493–498.
-
V. Ralevic and G. Burnstock. “Receptors for purines and pyrimidines”, Pharmacological Reviews; 1998; 50: 3; 413–492.
-
Kathrin Klein, Stefan Einter, MiiaTurpeinen, Matthias Scheab, Ulrich M. Zanger, Patheay- Targeted Pharmacogenomics of CYP1A2 in
-
Human Liver. 2010; 493–498.
-
Gunes, A., Dahl, M., Variation in CYP1A2 activity and its clinical implications: infl uence of environmental factors and genetic polymorphisms.2008; 625–637.
-
Marilyn, C., Cornelis., Ahmed El-Sohemy., Edmond K. Kabagambe., Hannia Campos, Coff ee, CYP1A2 Genotype, and Risk of, Myocardial Infarction.2006; 1135-1141.
-
Cornelis, M. C., El-Sohemy, A., Campos, H., Genetic polymorphism of CYP1A2 increases the risk ofmyocardial infarction. 2004; 41:758–762.
-
Caff eine-and-Activation-Theory-Eff ects-on-Health-and-Behavior-Smith; 2007; 493–498
References
Cammack, R., Oxford Dictionary of Biochemistry and Molecular Biology - Revised Edition. Oxford University Press; 2006; 493–498.
Kot, M. & Daniel, W.A., Caff eine as a marker substrate for testing cytochrome P450 activityin human and rat.Pharmacol Rep.2008; 60(6):789-797.
R. Viani, “The composition of coff ee”, in Caff eine, Coff ee and Health, S. Garatini, Ed. Raven Press, New York, NY, USA ; 1993; 17–41.
L. Missiaen, J. B. Parys, H. De Smedt, B. Himpens, and R. Casteels,“Inhibition of inositol trisphosphate-induced calcium release
by caff eine is prevented by ATP”, Biochemical Journal, 1994; 300:1; 81–84.
C. Martin, C. Dacquet, C. Mironneau, and J. Mirroneau, “Caff eine-induced inhibition of calcium channel current in cultured smooth muscle cells from pregnant rat myometrium”, British Journal of Pharmacology, 1989; 98; 2; 493–498.
V. Ralevic and G. Burnstock. “Receptors for purines and pyrimidines”, Pharmacological Reviews; 1998; 50: 3; 413–492.
Kathrin Klein, Stefan Einter, MiiaTurpeinen, Matthias Scheab, Ulrich M. Zanger, Patheay- Targeted Pharmacogenomics of CYP1A2 in
Human Liver. 2010; 493–498.
Gunes, A., Dahl, M., Variation in CYP1A2 activity and its clinical implications: infl uence of environmental factors and genetic polymorphisms.2008; 625–637.
Marilyn, C., Cornelis., Ahmed El-Sohemy., Edmond K. Kabagambe., Hannia Campos, Coff ee, CYP1A2 Genotype, and Risk of, Myocardial Infarction.2006; 1135-1141.
Cornelis, M. C., El-Sohemy, A., Campos, H., Genetic polymorphism of CYP1A2 increases the risk ofmyocardial infarction. 2004; 41:758–762.
Caff eine-and-Activation-Theory-Eff ects-on-Health-and-Behavior-Smith; 2007; 493–498
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