Idiopathic thrombocytopenic purpura in tuberculosis
DOI:
https://doi.org/10.55312/op.vi1.6225Abstract
Tuberculosis (TB) is a contagious disease in both developing and developed countries. The incidence is increasing due to bacilli resistant to many drugs and the human immunodeficiency virus (HIV). Since 2012, India has the highest incidence of the disease at around 2.2 million cases, accounting for 26% of the global incidence according to World Health Organization statistics. A wide range of hematological manifestations is observed in TB, where thrombocytopenia is common in miliary TB and thrombocytosis in pulmonary TB. Immune thrombocytopenic purpura (ITP) is characterized by a low platelet count accompanied by the presence of autoantibodies. The association of immune thrombocytopenic purpura and tuberculosis is a rare condition. In the case presented, anti-tuberculosis therapy was effective for both tuberculosis and thrombocytopenia, suggesting a causal link between tuberculosis and immune thrombocytopenic purpura.
Keywords:
PTI, thrombocytopenia, Mycobacterium tuberculosis,, TBC, antituberculous therapyDownloads
References
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References
1. Global Tuberculosis Report. Geneva: WHO; 2013. [Accessed 2013 Oct 26]. Annex 2 country profiles;
p. 122. Available from: http://www.who.int/tb/publications/global_report/en/ [Google Scholar]
2. Kashyap R, Chaudhary VP. Haematological manifestations of tuberculosis. In: Sharma SK, Mohan A,
editors. Tuberculosis. Neë Delhi: Jaypee Brothers Medical Publishers (P) Ltd.; 2006. pp. 370–9. [Google
Scholar]
3. Ali R, Ozkalemkas F, Ozçelik T, Ozkocaman V, Ozan U, Kimya Y, et al. Idiopathic thrombocytopenic
purpura in pregnancy: A single institutional experience ëith maternal and neonatal outcomes. Ann Hematol.
2003;82:348–52. [PubMed] [Google Scholar]
4. Liebman HA, Pullarkat V. Diagnosis and management of immune thrombocytopenia in the era of thrombopoietin
mimetics. Hematology Am Soc Hematol Educ Program. 2011;2011:384–90. [PubMed] [Google
Scholar]
5. Boots RJ, Roberts AW, McEvoy D. Immune thrombocytopenia complicating pulmonary tuberculosis:
Case report and investigation of mechanisms. Thorax. 1992;47:396–7. [PMC free article] [PubMed] [Google
Scholar]
6. Ursavas A, Edigar D, Ali R, Koprucuoglu D, Bahcetepe D, Kocamaz G, et al. Immune thrombocytopenia
associated ëith pulmonary tuberculosis. J Infect Chemother. 2010;16:42–4. [PubMed] [Google
Scholar]
7. Ghobrial MË, Albornoz MA. Immune thrombocytopenia: A rare presenting manifestation of tuberculosis.
Am J Hematol. 2001;67:139–43. [PubMed] [Google Scholar]
8. Kalra A, Kalra A, Palanisëamy C, Vikram N, Khilnani GC, Sood R. Immune thrombocytopenia in
a challenging case of disseminated tuberculosis: A case report and revieë of the literature. Case Rep
Med. 2010;2010:pii: 946278. [PMC free article] [PubMed] [Google Scholar]
9. Dagaonkar RS, Udëadia ZF. Disseminated tuberculosis ëith immune thrombocytopenic purpura. Lung
India. 2012;29:63–5. [PMC free article] [PubMed] [Google Scholar]
10. Jurak SS, Aster R, Saëaf H. Immune thrombocytopenia associated ëith tuberculosis. Clin Pediatr
(Phila) 1983;22:318–9. [PubMed] [Google Scholar]
11. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med. 2002;346:995–
1008. [PubMed] [Google Scholar]
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