Extracts of the plant Kudzu (Pueraria officinalis) and her semisynthetic derivative cvt 10216, as the new clinical therapy competitively with disulfiram, in the process of withdrawal and abstinence from alcohol
DOI:
https://doi.org/10.55312/op.vi2.4520Abstract
Today are well documented damages resulting from the chronic and abusive use of alcohol, where the liver is the most important tissue which break down the alcohol, we known conventional therapies such as Disulfi ram, Naltrexone and Acamphosate where clinical outcomes are aligned with side effects.Keywords:
Pueraria offi cinalis, ALDH2, alcohol, CVT 10216, dipsotropic.Downloads
References
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Arolfo M P, Overstreet D H, Yao L, Fan P, Lawrence A J, Tao G, et al. Suppression of heavy drinking and addictive drug-seeking by a novel ALDH-2 inhibitor. Alcohol Clin Res. 2009 [Electronic publication ahead of print, Aug 10, 2009.
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Overstreet, D H; Keung, W M; Tao, G.; Arolfo, M P; Yao, L; Zablocki, J, et al. Novel selective inhibitors of mitochondrial aldehyde dehydrogenase (ALDH2) reduce alcohol intake. Presented at the 30th annual meeting of the Research Society on Alcoholism; July 7–11; 2007; p. #530.
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Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001; 158:343–59. [PubMed: 11797055].
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Sinha R, Fox H C, Hong K A, Bergqist K, Bhagwagar Z, Siedlarz K M Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 2009; 34:1198–208. [PubMed: 18563062].
References
Arolfo M P, Overstreet D H, Yao L, Fan P, Lawrence A J, Tao G, et al. Suppression of heavy drinking and addictive drug-seeking by a novel ALDH-2 inhibitor. Alcohol Clin Res. 2009 [Electronic publication ahead of print, Aug 10, 2009.
Overstreet, D H; Keung, W M; Tao, G.; Arolfo, M P; Yao, L; Zablocki, J, et al. Novel selective inhibitors of mitochondrial aldehyde dehydrogenase (ALDH2) reduce alcohol intake. Presented at the 30th annual meeting of the Research Society on Alcoholism; July 7–11; 2007; p. #530.
Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001; 158:343–59. [PubMed: 11797055].
Sinha R, Fox H C, Hong K A, Bergqist K, Bhagwagar Z, Siedlarz K M Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 2009; 34:1198–208. [PubMed: 18563062].
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