Ekstraktet e bimës Kudzu (Pueraria officinalis) dhe derivati gjysmë sintetik i saj cv 10216, si terapia më e re klinike konkurruese e disulfiramit në procesin e lënies dhe abstinencës nga alkooli
DOI:
https://doi.org/10.55312/op.vi2.4520Abstract
Sot njihen më së miri dhe janë të dokumentuara dëmet që shoqërohen nga përdorimi kronik dhe abuziv me alkoolin, ku në plan të parë del dëmtimi i heparit si organi kryesor metabolues. Njëkohësisht, njihen dhe terapitë konvencionale si disulfi ram, naltrekson dhe acamphosate, ku rezultatet klinike shkojnë paralelisht me efektet anësore.Parole chiave:
pueraria offi cinalis, ALDH2, alkooli, CVT 10216, dipsotropik.Downloads
Riferimenti bibliografici
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Arolfo M P, Overstreet D H, Yao L, Fan P, Lawrence A J, Tao G, et al. Suppression of heavy drinking and addictive drug-seeking by a novel ALDH-2 inhibitor. Alcohol Clin Res. 2009 [Electronic publication ahead of print, Aug 10, 2009.
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Overstreet, D H; Keung, W M; Tao, G.; Arolfo, M P; Yao, L; Zablocki, J, et al. Novel selective inhibitors of mitochondrial aldehyde dehydrogenase (ALDH2) reduce alcohol intake. Presented at the 30th annual meeting of the Research Society on Alcoholism; July 7–11; 2007; p. #530.
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Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001; 158:343–59. [PubMed: 11797055].
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Sinha R, Fox H C, Hong K A, Bergqist K, Bhagwagar Z, Siedlarz K M Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 2009; 34:1198–208. [PubMed: 18563062].
Riferimenti bibliografici
Arolfo M P, Overstreet D H, Yao L, Fan P, Lawrence A J, Tao G, et al. Suppression of heavy drinking and addictive drug-seeking by a novel ALDH-2 inhibitor. Alcohol Clin Res. 2009 [Electronic publication ahead of print, Aug 10, 2009.
Overstreet, D H; Keung, W M; Tao, G.; Arolfo, M P; Yao, L; Zablocki, J, et al. Novel selective inhibitors of mitochondrial aldehyde dehydrogenase (ALDH2) reduce alcohol intake. Presented at the 30th annual meeting of the Research Society on Alcoholism; July 7–11; 2007; p. #530.
Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001; 158:343–59. [PubMed: 11797055].
Sinha R, Fox H C, Hong K A, Bergqist K, Bhagwagar Z, Siedlarz K M Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 2009; 34:1198–208. [PubMed: 18563062].
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